TUNING HELP!

I often switch tunings on one guitar from that I use from DADGAD, to DADGBE, then to C#F#C#F#BE. I finished building a 24 Tet quarter tonal neck this summer and these are the best tunings to get the most out of this guitar. Would locking tuners be detrimental, long term, to my guitar and strings? I have a set of locking tuners for my main axe and love them, but didn’t know if switching tunings so often (all three tunings in one session, sometimes) wouldn’t be a good combination. Might be a stupid question but I’m just not sure. Pic for reference. Thanks for getting this far:)

Tl;dr I ruined a perfectly good guitar and want to know if locking tuners aren’t the best idea if I retune it extremely often when I play.

I often switch tunings on one guitar from that I use from DADGAD, to DADGBE, then to C#F#C#F#BE. I finished building a 24 Tet quarter tonal neck this summer and these are the best tunings to get the most out of this guitar. Would locking tuners be detrimental, long term, to my guitar and strings? I have a set of locking tuners for my main axe and love them, but didn’t know if switching tunings so often (all three tunings in one session, sometimes) wouldn’t be a good combination. Might be a stupid question but I’m just not sure. Pic for reference. Thanks for getting this far:)

Tl;dr I ruined a perfectly good guitar and want to know if locking tuners aren’t the best idea if I retune it extremely often when I play.